Abstract
Sheehan and Nadarajah et al.1 identified that Bmal1 loss from astrocytes induces the expression of BAG3, a macroautophagy chaperone enriched in Alzheimer's disease patients and in disease-associated astrocytes, enhancing the phagocytosis of misfolded proteins and preventing tau and alpha-synuclein pathologies.
Copyright © 2023 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
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Comment
MeSH terms
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Adaptor Proteins, Signal Transducing / metabolism
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Alzheimer Disease* / metabolism
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Apoptosis Regulatory Proteins / metabolism
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Astrocytes* / metabolism
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Humans
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Phagocytosis
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alpha-Synuclein / metabolism
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tau Proteins / metabolism
Substances
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tau Proteins
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alpha-Synuclein
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BAG3 protein, human
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Adaptor Proteins, Signal Transducing
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Apoptosis Regulatory Proteins