Timing matters: A protective role of astrocyte reactivity in neurodegeneration

Neuron. 2023 Aug 2;111(15):2277-2279. doi: 10.1016/j.neuron.2023.06.014.

Abstract

Sheehan and Nadarajah et al.1 identified that Bmal1 loss from astrocytes induces the expression of BAG3, a macroautophagy chaperone enriched in Alzheimer's disease patients and in disease-associated astrocytes, enhancing the phagocytosis of misfolded proteins and preventing tau and alpha-synuclein pathologies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism
  • Alzheimer Disease* / metabolism
  • Apoptosis Regulatory Proteins / metabolism
  • Astrocytes* / metabolism
  • Humans
  • Phagocytosis
  • alpha-Synuclein / metabolism
  • tau Proteins / metabolism

Substances

  • tau Proteins
  • alpha-Synuclein
  • BAG3 protein, human
  • Adaptor Proteins, Signal Transducing
  • Apoptosis Regulatory Proteins