Current progress of pig models for liver cancer research

Luyao Wang; Yuexian Piao; Fucheng Guo; Jiarui Wei; Yurong Chen; Xiangpeng Dai; Xiaoling Zhang

doi:10.1016/j.biopha.2023.115256

Current progress of pig models for liver cancer research

Biomed Pharmacother. 2023 Sep:165:115256. doi: 10.1016/j.biopha.2023.115256. Epub 2023 Aug 1.

Authors

Luyao Wang¹, Yuexian Piao², Fucheng Guo¹, Jiarui Wei¹, Yurong Chen¹, Xiangpeng Dai³, Xiaoling Zhang⁴

Affiliations

¹ Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital of Jilin University, Changchun, China; National-Local Joint Engineering Laboratory of Animal Models for Human Disease, First Hospital of Jilin University, Changchun, China.
² Invasive Technology Nursing Platform, First Hospital of Jilin University, Changchun, China.
³ Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital of Jilin University, Changchun, China; National-Local Joint Engineering Laboratory of Animal Models for Human Disease, First Hospital of Jilin University, Changchun, China. Electronic address: daixiangpeng@jlu.edu.cn.
⁴ Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital of Jilin University, Changchun, China; National-Local Joint Engineering Laboratory of Animal Models for Human Disease, First Hospital of Jilin University, Changchun, China. Electronic address: xiaolingzhang@jlu.edu.cn.

PMID: 37536038
DOI: 10.1016/j.biopha.2023.115256

Abstract

Preclinical trials play critical roles in assessing the safety and efficiency of novel therapeutic strategies for human diseases including live cancer. However, most therapeutic strategies that were proved to be effective in preclinical cancer models failed in human clinical trials due to the lack of appropriate disease animal models. Therefore, it is of importance and urgent to develop a precise animal model for preclinical cancer research. Liver cancer is one of the most frequently diagnosed cancers with low 5-year survival rate. Recently, porcine attracted increasing attentions as animal model in biomedical research. Porcine liver cancer model may provide a promising platform for biomedical research due to their similarities to human being in body size, anatomical characteristics, physiology and pathophysiology. In this review, we comprehensively summarized and discussed the advantages and disadvantages, rationale, current status and progress of pig models for liver cancer research.

Keywords: Animal model; Crispr/Cas9; Liver cancer; Oncopig; Porcine.

Publication types

Review

MeSH terms

Animals
Biomedical Research*
Disease Models, Animal
Humans
Liver Neoplasms*
Swine