The role of mtDAMPs in the trauma-induced systemic inflammatory response syndrome

Jingjing Ye; Xiaodan Hu; Zhiwei Wang; Rui Li; Lebin Gan; Mengwei Zhang; Tianbing Wang

doi:10.3389/fimmu.2023.1164187

The role of mtDAMPs in the trauma-induced systemic inflammatory response syndrome

Front Immunol. 2023 Jul 18:14:1164187. doi: 10.3389/fimmu.2023.1164187. eCollection 2023.

Authors

Jingjing Ye¹, Xiaodan Hu^{1

2}, Zhiwei Wang³, Rui Li¹, Lebin Gan¹, Mengwei Zhang¹, Tianbing Wang¹

Affiliations

¹ Trauma Center, Peking University People's Hospital, Key Laboratory of Trauma Treatment and Neural Regeneration (Peking University) Ministry of Education, National Center for Trauma Medicine of China, Beijing, China.
² School of Basic Medicine, Peking University, Beijing, China.
³ Orthopedics Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Abstract

Systemic inflammatory response syndrome (SIRS) is a non-specific exaggerated defense response caused by infectious or non-infectious stressors such as trauma, burn, surgery, ischemia and reperfusion, and malignancy, which can eventually lead to an uncontrolled inflammatory response. In addition to the early mortality due to the "first hits" after trauma, the trauma-induced SIRS and multiple organ dysfunction syndrome (MODS) are the main reasons for the poor prognosis of trauma patients as "second hits". Unlike infection-induced SIRS caused by pathogen-associated molecular patterns (PAMPs), trauma-induced SIRS is mainly mediated by damage-associated molecular patterns (DAMPs) including mitochondrial DAMPs (mtDAMPs). MtDAMPs released after trauma-induced mitochondrial injury, including mitochondrial DNA (mtDNA) and mitochondrial formyl peptides (mtFPs), can activate inflammatory response through multiple inflammatory signaling pathways. This review summarizes the role and mechanism of mtDAMPs in the occurrence and development of trauma-induced SIRS.

Keywords: mtDAMPs; mtDNA; mtFPs; trauma; trauma-induced SIRS.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

DNA, Mitochondrial / genetics
DNA, Mitochondrial / metabolism
Humans
Mitochondria* / metabolism
Peptides / metabolism
Signal Transduction
Systemic Inflammatory Response Syndrome* / pathology

Substances

DNA, Mitochondrial
Peptides

Grants and funding

Natural Science Foundation of Beijing (7222193), National Natural Science Foundation of China (82000348), Research and Development Fund of Peking University People’s Hospital (RDY2020-05, RDX2021-09), UMHS-PUHSC Joint Institute Grant (BMU 2020JI007), and Medical Science and Technology joint project of Henan Province (LHGJ20220356).