lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation

Wenming Chen; Wei Zhao; Minghui Hao; Yuping Wang

doi:10.1515/med-2023-0738

lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation

Open Med (Wars). 2023 Jul 25;18(1):20230738. doi: 10.1515/med-2023-0738. eCollection 2023.

Authors

Wenming Chen¹, Wei Zhao², Minghui Hao², Yuping Wang²

Affiliations

¹ Department of Cardiology, Beijing Luhe Hospital, Capital Medical University, No. 82, Xinhua South Street, Tongzhou District, Beijing City, 101100, PR China.
² Department of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing City, 101100, PR China.

Abstract

UCA1 is predicted to bind to miR-132, which is a key player in the proliferation of vascular smooth muscle cells (VSMCs). This research studied the role of lncRNA UCA1 in atherosclerosis. The binding of UCA1 to miR-132 was proved by dual luciferase activity assay and RNA immunoprecipitation. UCA1 and miR-132 failed to affect each other's expression in VSMCs. UCA1 was upregulated and miR-132 was decreased in atherosclerosis plasma. However, they are not closely correlated across atherosclerosis and control plasma sample. Interestingly, UCA1 suppressed the role of miR-132 in downregulating Lrrfip1 expression and promoting VSMC proliferation. Therefore, UCA1 is downregulated in atherosclerosis and may regulate miR-132/Lrrfip1 axis to promote VSMC proliferation.

Keywords: Lrrfip1; atherosclerosis; lncRNA UCA1; miR-132; proliferation.