Transconjunctival XEN45 implantation for secondary open-angle glaucoma management in a pediatric patient with WAGR syndrome

Brooklyn Rawlyk; Mitchell D Thatcher; Shehla Rubab; Maria Gabriela Campos-Baniak

doi:10.1016/j.ajoc.2023.101888

Transconjunctival XEN45 implantation for secondary open-angle glaucoma management in a pediatric patient with WAGR syndrome

Am J Ophthalmol Case Rep. 2023 Jul 7:32:101888. doi: 10.1016/j.ajoc.2023.101888. eCollection 2023 Dec.

Authors

Brooklyn Rawlyk¹, Mitchell D Thatcher^{1

2}, Shehla Rubab², Maria Gabriela Campos-Baniak²

Affiliations

¹ College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
² Department of Ophthalmology, University of Saskatchewan, Saskatoon, SK, Canada.

Abstract

Purpose: To report a case of XEN45 gel stent implantation in a pediatric patient with WAGR syndrome as a successful surgical intervention in the management of multifactorial secondary open-angle glaucoma.

Observations: A 6-year-old female with a history of WAGR syndrome, bilateral congenital aniridia, pseudophakia OD and glaucoma OD, was referred for a XEN45 gel stent OD. IOP was persistently elevated at 24 mm Hg despite two glaucoma medications. Implantation of the XEN45 gel stent was performed using a transconjunctival ab externo approach. There were no significant intra-or-postoperative adverse events associated with the stent. The patient achieved good IOP-lowering control without glaucoma medications across the 18-month follow-up period.

Conclusions: A XEN45 stent through a transconjunctival ab externo approach may be an effective surgical intervention in pediatric patients with secondary open-angle glaucoma associated with aniridia and aphakia.

Keywords: Aniridia; Aphakia; Glaucoma surgery; MIGS; Pediatric glaucoma; Secondary open-angle glaucoma; WAGR syndrome; XEN45 gel stent.

Publication types

Case Reports