Cys-regulation: oxidized CHK1 controls cross-compartment circuit of chemoresistance

Nathan P Ward

doi:10.1016/j.trecan.2023.07.005

Cys-regulation: oxidized CHK1 controls cross-compartment circuit of chemoresistance

Trends Cancer. 2023 Sep;9(9):700-702. doi: 10.1016/j.trecan.2023.07.005. Epub 2023 Aug 1.

Author

Nathan P Ward¹

Affiliation

¹ Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA. Electronic address: nathan.ward@moffitt.org.

PMID: 37532649
DOI: 10.1016/j.trecan.2023.07.005

Abstract

In a recent study published in Cell, Zhang et al. integrate genome-wide CRISPRi screening with cysteine chemoproteomics to identify functionally relevant oxidation events associated with the cellular response to chemotherapy. This work uncovered checkpoint kinase 1 (CHK1) as a nuclear reactive oxygen species (ROS) sensor that mediates chemoresistance through the suppression of mitochondrial protein synthesis.

Keywords: CHK1; ROS; SSBP1; chemoresistance; redox.

Publication types

Comment

MeSH terms

Checkpoint Kinase 1 / genetics
Checkpoint Kinase 1 / metabolism
Cysteine* / metabolism
Drug Resistance, Neoplasm* / genetics
Humans
Oxidation-Reduction
Reactive Oxygen Species / metabolism

Substances

Cysteine
Checkpoint Kinase 1
Reactive Oxygen Species