Highly effective synthesis of 5-hydroxymethylfurfural from lignocellulosic biomass over a green and one-pot reaction in biphasic system

Quang Tam Huynh; Chong-Ting Zhong; Qing Huang; Yuan-Chung Lin; Ku-Fan Chen; Chien-Sen Liao; Cheng-Di Dong; Ken-Lin Chang

doi:10.1016/j.biortech.2023.129590

Highly effective synthesis of 5-hydroxymethylfurfural from lignocellulosic biomass over a green and one-pot reaction in biphasic system

Bioresour Technol. 2023 Nov:387:129590. doi: 10.1016/j.biortech.2023.129590. Epub 2023 Jul 31.

Authors

Quang Tam Huynh¹, Chong-Ting Zhong¹, Qing Huang², Yuan-Chung Lin³, Ku-Fan Chen⁴, Chien-Sen Liao⁵, Cheng-Di Dong⁶, Ken-Lin Chang⁷

Affiliations

¹ Institute of Environmental Engineering, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
² Key Laboratory for Environmental Toxicology of Haikou, Hainan University, Haikou, Hainan 570228, China.
³ Institute of Environmental Engineering, National Sun Yat-Sen University, Kaohsiung 804, Taiwan; Center for Emerging Contaminants Research, National Sun Yat-Sen University, Kaohsiung 804, Taiwan; Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
⁴ Department of Civil Engineering, National Chi Nan University, Nantou 545, Taiwan.
⁵ Department of Biological Science & Technology, I Shou University, Kaohsiung 840, Taiwan.
⁶ Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung 811, Taiwan.
⁷ Institute of Environmental Engineering, National Sun Yat-Sen University, Kaohsiung 804, Taiwan; Center for Emerging Contaminants Research, National Sun Yat-Sen University, Kaohsiung 804, Taiwan; Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: klchang@mail.nsysu.edu.tw.

PMID: 37532059
DOI: 10.1016/j.biortech.2023.129590

Abstract

In this study, different types of lignocellulosic biomas were used as substrates for the conversion to 5-HMF via biphasic reaction system that is composed of a reaction phase (aqueous phase) and an extraction phase (organic phase) under the catalysis of various metal salts. Deep eutectic solvents (DESs), ionic liquid [BMIM]Cl, aqueous choline chloride, aqueous betaine hydrochloride, and ethylamine hydrochloride were used as the reaction phase in the combination of dimethyl sulfoxide (DMSO) as organic solvents. The highest yields of 5-HMF obtained from pineapple stems in reactions with DES were 40.98%, 37.26%, and 23.44% for ChCl:Lac, ChCl:OA, and EaCl:Lac, respectively. Moreover, the combination of dimethyl sulfoxide, betaine hydrochloride aqueous solution, and AlCl₃·6H₂O with the pineapple stem conversion system resulted in a maximum yield of 61.04% ± 0.55% of 5-HMF. This study also demonstrated that AlCl₃·6H₂O and betaine hydrochloride could be effectively reused four times, which indicates a green and effective process.

Keywords: 5-Hydroxymethylfurfural; Betaine hydrochloride; Biphasic systems; Deep eutectic solvents; Platform chemicals.

MeSH terms

Betaine*
Biomass
Dimethyl Sulfoxide*
Solvents
Water

Substances

lignocellulose
Dimethyl Sulfoxide
Betaine
5-hydroxymethylfurfural
Solvents
Water