Antibacterial activity of novel bacterial topoisomerase inhibitors against key veterinary pathogens

Hilary A Phelps; Michael Kuhn; Yanran Lu; Sandip Vibhute; Jeffrey L Watts; Mark J Mitton-Fry

doi:10.1016/j.vetmic.2023.109840

Antibacterial activity of novel bacterial topoisomerase inhibitors against key veterinary pathogens

Vet Microbiol. 2023 Sep:284:109840. doi: 10.1016/j.vetmic.2023.109840. Epub 2023 Jul 29.

Authors

Hilary A Phelps¹, Michael Kuhn¹, Yanran Lu², Sandip Vibhute², Jeffrey L Watts¹, Mark J Mitton-Fry³

Affiliations

¹ Global Therapeutics, Anti-Infectives Research, Zoetis, 333 Portage Street, Kalamazoo, MI 49007, United States.
² Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, United States.
³ Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, United States. Electronic address: mitton-fry.1@osu.edu.

PMID: 37531840
DOI: 10.1016/j.vetmic.2023.109840

Abstract

Multidrug-resistant bacteria infect companion animals and livestock in addition to their devastating impact on human health. Novel Bacterial Topoisomerase Inhibitors (NBTIs) with excellent activity against Gram-positive bacteria have previously been identified as promising new antibacterial agents. Herein, we evaluate the antibacterial activity of these NBTIs against a variety of important veterinary pathogens and demonstrate outstanding in vitro activity, especially against staphylococci.

Keywords: Antagonists & Inhibitors; Mastitis; Staphylococcus.

MeSH terms

Animals
Anti-Bacterial Agents / pharmacology
Bacteria*
Gram-Positive Bacteria
Humans
Microbial Sensitivity Tests / veterinary
Structure-Activity Relationship
Topoisomerase Inhibitors* / pharmacology

Substances

Topoisomerase Inhibitors
Anti-Bacterial Agents