Expression and prognostic value of Cripto-1 in early non-small cell lung cancer

Jian Zhong; Li Li; Qian Zhang; Jue Zou; Wei Liu; Chun Hua Xu

doi:10.1111/crj.13680

Expression and prognostic value of Cripto-1 in early non-small cell lung cancer

Clin Respir J. 2023 Dec;17(12):1203-1208. doi: 10.1111/crj.13680. Epub 2023 Aug 1.

Authors

Jian Zhong¹, Li Li^{2

3}, Qian Zhang^{2

3}, Jue Zou⁴, Wei Liu², Chun Hua Xu^{2

3}

Affiliations

¹ Department of Thoracic Surgery, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
² Department of Respiratory Medicine, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
³ Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, China.
⁴ Department of Pathology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.

Abstract

Objective: We aim to explore the expression of Cripto-1 (CR-1) protein in patients with early stage non-small cell lung cancer (NSCLC).

Methods: We investigated CR-1 expression status in specimens obtained from 240 patients with resected NSCLC and 30 cases of para-carcinous normal lung tissues.

Results: Compared with normal lung tissue, the positive expression of CR-1 protein in NSCLC was significantly increased (p < 0.005). Cox multivariate regression analysis showed that the expression of CR-1 protein was an independent prognostic factor for early stage NSCLC (p = 0.002).

Conclusion: Detecting CR-1 protein can predict the prognosis and recurrence in patients with NSCLC.

Keywords: Cripto-1; NSCLC; prognosis; recurrence.

MeSH terms

Biomarkers, Tumor / metabolism
Carcinoma, Non-Small-Cell Lung* / pathology
Disease-Free Survival
Humans
Intercellular Signaling Peptides and Proteins / genetics
Kaplan-Meier Estimate
Lung Neoplasms* / pathology
Neoplasm Staging
Prognosis
Small Cell Lung Carcinoma*

Substances

Biomarkers, Tumor
Intercellular Signaling Peptides and Proteins