The majority of polymer-based materials demonstrate expansion upon absorbing water from the air. Mechanical metamaterials provide an interesting way to achieve unusual hygroscopic deformation. However, previous studies have only accommodated the limited tunability of negative hygroscopic expansion by theoretical analysis but have never involved other deformation modes. This work proposes modular reprogrammable 3D moisture-sensitive mechanical metamaterials with switchable hygroscopic deformation modes, which are built up of multi-material 3D-printed bi-material curved strips and cubic nodes. Depending on the geometrical parameters and spatial layouts of the curved strips, the metamaterials exhibit tunable coefficient of hygroscopic expansion from negative to positive. In addition to homogeneous deformation, complex 3D hygroscopic deformation modes can be achieved including shear and twist. More interestingly, the metamaterials are reprogrammable since all the deformation modes can be switched by modular disassembling and reassembling of the curved strips, just like LEGO building blocks. This work demonstrates a feasible approach to achieve customized 3D hygroscopic deformation through easy block building for specific engineering applications including eliminating hygroscopic stress, shape morphing structures, and smart actuators.