Repurposing Marketed Drugs as Antidepressants with In Silico, In Vivo, and In Vitro Screening Methods

Abstract

Drug repurposing is a strategy to identify new therapeutic uses for marketed drugs, discontinued or shelved drugs, and drug candidates in clinical development. Drug repurposing has gained momentum over the past few years. A slow rate of new drug discovery and higher cost of new drug development attracted the attention for repurposing and repositioning of old medications . A deeper understanding of the pathogenesis of depression encourages novel discoveries through drug repurposing to treat depression. In this study, indole- and isatin-containing drugs are going to be repurposed using computational methods for the treatment of depression.

Keywords: Depression; Indole; Isatin; Virtual screening.