Genomic analysis and characterization of bacteriophage vB_SpuS_NX263 infecting Salmonella enterica subsp. enterica serovar Pullorum

Arch Virol. 2023 Jul 31;168(8):216. doi: 10.1007/s00705-023-05841-3.

Abstract

In this study, a new Salmonella phage, NX263, was isolated from sewage. This phage could lyse 90.57% (48/53) of the bacterial strains tested and showed good activity over a wide range of temperature (up to 60°C) and pH (5-10). Phylogenetic analysis showed that it should be classified as a member of the genus Skatevirus. The genome of phage NX263 is 46,574 bp in length with a GC content of 45.52%. It contains 89 open reading frames and two tRNA genes. No lysogeny, drug resistance, or virulence-associated genes were identified in the genome sequence, suggesting that this phage could potentially be used to treat Salmonella Pullorum infections.

MeSH terms

  • Bacteriophages* / classification
  • Bacteriophages* / genetics
  • Bacteriophages* / isolation & purification
  • Genome, Viral* / genetics
  • Phylogeny
  • Salmonella enterica* / virology