Adult zebrafish as advanced models of human disease

Dis Model Mech. 2023 Aug 1;16(8):dmm050351. doi: 10.1242/dmm.050351. Epub 2023 Jul 31.

Abstract

Modelling adult diseases to understand their aetiology and progression, and to develop new therapies, is a major challenge for medical biology. We are excited by new efforts in the zebrafish community to develop models of adult diseases that range from cancer to heart, infectious and age-related diseases, and those that relate to toxicology and complex social behaviours. Here, we discuss some of the advances in the field of zebrafish models of adult disease, and where we see opportunities and challenges ahead.

Keywords: Adult zebrafish; Disease modelling; Human disease.

MeSH terms

  • Adult
  • Animals
  • Disease Models, Animal
  • Heart
  • Humans
  • Neoplasms*
  • Social Behavior
  • Zebrafish*