Is There a Predictable Cost-Benefit Ratio in Preeclampsia?

Dogukan Ozkan; Betul Tokgoz Cakir; Ceren Polat Kamaci; Merve Ozkan; Cantekin Iskender; Omer Tapisiz; Yaprak Engin-Üstün

doi:10.7759/cureus.41051

Is There a Predictable Cost-Benefit Ratio in Preeclampsia?

Cureus. 2023 Jun 27;15(6):e41051. doi: 10.7759/cureus.41051. eCollection 2023 Jun.

Authors

Dogukan Ozkan¹, Betul Tokgoz Cakir¹, Ceren Polat Kamaci¹, Merve Ozkan¹, Cantekin Iskender¹, Omer Tapisiz¹, Yaprak Engin-Üstün^{2

3}

Affiliations

¹ Obstetrics and Gynaecology, Etlik Zübeyde Hanim EAH, Ankara, TUR.
² Obstetrics and Gynecology, University of Health Sciences Etlik Zübeyde Hanim Women's Health Training and Research Hospital, Ankara, TUR.
³ Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, TUR.

Abstract

Background Preeclampsia (PE) is one of the highest-risk pregnancies and a complicated condition that occurs in 2% to 8% of pregnancies and is associated with markers of a systemic inflammatory response (SIR). In this study, we aimed to determine the role of these markers in predicting PE. Methodology A total of 300 women with singleton pregnancies and cephalic presentation were included in the study. Normotensive pregnant women (n = 149) who met this criterion were included as the control group Pregnant women who met the inclusion criteria for a diagnosis of preeclampsia (n = 151) were included in the study group. Results The baseline characteristics of the study groups showed no significant difference. The hypertensive group was hospitalized significantly earlier than the control group (p < 0.001). We found significantly higher systolic and diastolic blood pressure values in the PE group than in the other group (p < 0.001). The mean neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and aspartate aminotransferase-to-platelet ratio index (APRI) values at hospitalization did not differ significantly between groups (p = 0.639, p = 0.709, and p = 0.066, respectively). In the receiver operating characteristic analysis curves compared with the control group and PE, none of the parameters could predict PE. Conclusions We found that NLR, PLR, and APRI have no clinical significance in assessing developmental risk and predicting PE.

Keywords: aspartate aminotransferase platelet ratio index (apri); gestational hypertension; neutrophil lymphocyte ratio (nlr); platelet lymphocyte ratio (plr); preeclampsia; severe preeclampsia.