Progress of regulatory RNA in small extracellular vesicles in colorectal cancer

Xinyi Hu; Yukang Lu; Jiajun Zhou; Lanfeng Wang; Mengting Zhang; Yiping Mao; Zhiping Chen

doi:10.3389/fcell.2023.1225965

Progress of regulatory RNA in small extracellular vesicles in colorectal cancer

Front Cell Dev Biol. 2023 Jul 12:11:1225965. doi: 10.3389/fcell.2023.1225965. eCollection 2023.

Authors

Xinyi Hu^{1

2}, Yukang Lu^{1

2}, Jiajun Zhou², Lanfeng Wang³, Mengting Zhang^{1

2}, Yiping Mao^{1

2}, Zhiping Chen^{1

2}

Affiliations

¹ The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China.
² Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
³ Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

Abstract

Colorectal cancer (CRC) is the second most common malignant tumor of the gastrointestinal tract with the second highest mortality rate and the third highest incidence rate. Early diagnosis and treatment are important measures to reduce CRC mortality. Small extracellular vesicles (sEVs) have emerged as key mediators that facilitate communication between tumor cells and various other cells, playing a significant role in the growth, invasion, and metastasis of cancer cells. Regulatory RNAs have been identified as potential biomarkers for early diagnosis and prognosis of CRC, serving as crucial factors in promoting CRC cell proliferation, invasion and metastasis, angiogenesis, drug resistance, and immune cell differentiation. This review provides a comprehensive summary of the vital role of sEVs as biomarkers in CRC diagnosis and their potential application in CRC treatment, highlighting their importance as a promising avenue for further research and clinical translation.

Keywords: engineered extracellular vesicles; extracellular vesicles; renal cell carcinoma; tumor microenvironment; tumor vaccine.

Publication types

Review

Grants and funding

This research was funded by the Natural Science Foundation of Jiangxi Province, grant number 20202BABL206119, Science and Technology Plan of Jiangxi Health and Family Planning Commission, grant number 202310839, Science and Technology Plan of Jiangxi Health and Family Planning Commission, grant number 202210860, Science and Technology Plan of Gannan Medical University First Affiliated Hospital, grant number YJYB202110, Guiding Science and Technology Plan of Ganzhou, grant number GZ2021ZSF004.