AUC-based monitoring and model-informed precision dosing of vancomycin in critically ill patients: why and how?

Sylvain Goutelle; Florent Wallet; Yann Thoma; Jean-Rémi Peclard; Laurent Bourguignon; Sabine Cohen; Eric Kipnis; Jason Roberts; Bernard Allaouchiche; Arnaud Friggeri

doi:10.1016/j.accpm.2023.101286

AUC-based monitoring and model-informed precision dosing of vancomycin in critically ill patients: why and how?

Anaesth Crit Care Pain Med. 2023 Dec;42(6):101286. doi: 10.1016/j.accpm.2023.101286. Epub 2023 Jul 28.

Authors

Affiliations

¹ Hospices Civils de Lyon, Groupement Hospitalier Nord, Service de Pharmacie, Lyon, France; Université of Lyon, Université Claude Bernard Lyon 1, UMR CNRS 5558, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France; Université of Lyon, Université Claude Bernard Lyon 1, Facultés de Médecine et de Pharmacie de Lyon, Lyon, France. Electronic address: sylvain.goutelle@chu-lyon.fr.
² Hospices Civils de Lyon, GH Sud, Services d'Anesthésie-réanimation Médecine Intensive, Lyon, France; Université of Lyon, Université Claude Bernard Lyon 1, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Lyon, France.
³ School of Management and Engineering Vaud (HEIG-VD), HES-SO University of Applied Sciences and Arts Western Switzerland, Yverdon-les-Bains, Switzerland.
⁴ Hospices Civils de Lyon, Groupement Hospitalier Nord, Service de Pharmacie, Lyon, France; Université of Lyon, Université Claude Bernard Lyon 1, UMR CNRS 5558, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France; Université of Lyon, Université Claude Bernard Lyon 1, Facultés de Médecine et de Pharmacie de Lyon, Lyon, France.
⁵ Hospices Civils de Lyon, GH Sud, Laboratoire de Pharmaco-toxicologie, France.
⁶ Université of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, Lille, France.
⁷ University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia; Herston Infectious Diseases Institute (HeIDI), Metro North Health, Brisbane, Australia; Departments of Pharmacy and Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France.
⁸ Université of Lyon, Université Claude Bernard Lyon 1, Facultés de Médecine et de Pharmacie de Lyon, Lyon, France; Hospices Civils de Lyon, GH Sud, Services d'Anesthésie-réanimation Médecine Intensive, Lyon, France; Lyon University, VetAgro Sup, Lyon Veterinary Campus, UPSP 2016. A101, Pulmonary and Cardiovascular Agression in Sepsis, Marcy l'Étoile, France.
⁹ Université of Lyon, Université Claude Bernard Lyon 1, Facultés de Médecine et de Pharmacie de Lyon, Lyon, France; Hospices Civils de Lyon, GH Sud, Services d'Anesthésie-réanimation Médecine Intensive, Lyon, France; Université of Lyon, Université Claude Bernard Lyon 1, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Lyon, France.

PMID: 37517689
DOI: 10.1016/j.accpm.2023.101286

No abstract available

Keywords: Model-Informed precision dosing; Therapeutic drug-monitoring; Vancomycin.

MeSH terms

Anti-Bacterial Agents / therapeutic use
Area Under Curve
Critical Illness* / therapy
Humans
Infusions, Intravenous
Vancomycin*

Substances

Vancomycin
Anti-Bacterial Agents