Recent advances in strategies to target the behavior of macrophages in wound healing

Hongkun Zheng; Xinwei Cheng; Lu Jin; Shengzhou Shan; Jun Yang; Jia Zhou

doi:10.1016/j.biopha.2023.115199

Recent advances in strategies to target the behavior of macrophages in wound healing

Biomed Pharmacother. 2023 Sep:165:115199. doi: 10.1016/j.biopha.2023.115199. Epub 2023 Jul 28.

Authors

Hongkun Zheng¹, Xinwei Cheng¹, Lu Jin², Shengzhou Shan¹, Jun Yang³, Jia Zhou⁴

Affiliations

¹ Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
² Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
³ Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. Electronic address: yj55569@sina.com.
⁴ Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. Electronic address: joyjb@163.com.

PMID: 37517288
DOI: 10.1016/j.biopha.2023.115199

Abstract

Chronic wounds and scar formation are widespread due to limited suitable remedies. The macrophage is a crucial regulator in wound healing, controlling the onset and termination of inflammation and regulating other processes related to wound healing. The current breakthroughs in developing new medications and drug delivery methods have enabled the accurate targeting of macrophages in oncology and rheumatic disease therapies through clinical trials. These successes have cleared the way to utilize drugs targeting macrophages in various disorders. This review thus summarizes macrophage involvement in normal and pathologic wound healing. It further details the targets available for macrophage intervention and therapeutic strategies for targeting the behavior of macrophages in tissue repair and regeneration.

Keywords: Chronic wounds; Macrophages; Scar; Targeted therapy; Wound healing.

Publication types

Review

MeSH terms

Cicatrix*
Drug Delivery Systems
Humans
Macrophages / physiology
Wound Healing* / physiology