AI-based AlphaFold2 significantly expands the structural space of the autophagy pathway

Autophagy. 2023 Dec;19(12):3201-3220. doi: 10.1080/15548627.2023.2238578. Epub 2023 Jul 30.

Abstract

AF2: AlphaFold2; AF2-Mult: AlphaFold2 multimer; ATG: autophagy-related; CTD: C-terminal domain; ECTD: extreme C-terminal domain; FR: flexible region; MD: molecular dynamics; NTD: N-terminal domain; pLDDT: predicted local distance difference test; UBL: ubiquitin-like.

Keywords: ATG7-ATG10 complex; AlphaFold2; autophagic interactome; autophagy; molecular dynamics simulations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Artificial Intelligence
  • Autophagy*
  • Autophagy-Related Proteins
  • Furylfuramide
  • Ubiquitin-Conjugating Enzymes* / metabolism

Substances

  • Ubiquitin-Conjugating Enzymes
  • Furylfuramide
  • Autophagy-Related Proteins