Relationship of circulating resistin levels with muscle mass determined by bioelectrical impedance in females with obesity

Abstract

Introduction: Serum resistin levels have been associated with obesity, visceral fat, and insulin resistance. Its relationship with muscle mass has been less evaluated.

Objectives: to evaluate the relationship between muscle mass determined by electrical bioimpedance and circulating resistin levels in obese women over 60 years of age.

Methods: We conducted a cross-sectional study in 313 obese women. Anthropometric data (weight, height, body mass index (BMI) and waist circumference), BIA parameters (total fat mass (TFM), fat-free mass (FFM), fat-free mass index (FFMI)), skeletal muscle mass (SMM) and skeletal muscle mass index (SMI)), blood pressure and laboratory tests were recorded.

Results: Patients were divided into two different groups according to the mean value of SMI (11.93 kg/m²): low SMI versus high SMI. In the low SMI group, the resistin levels were higher than the resistin levels in the high SMI group (delta value: 2.8 + 0.3 ng/dl:p = 0.01). Serum resistin levels are inversely correlated with FFM, FFMI, SMM, and SMI. This adipokine shows a positive correlation with insulin, HOMA-IR and PCR levels. In the model with SMI as the dependent variable, resistin levels explained 12% of the variability in muscle mass (Beta -0.38, 95% CI -0.91 to -0.11).

Conclusions: Serum resistin levels are associated with low skeletal muscle mass in obese women over 60 years of age.

Keywords: Electrical bioimpedance; Impedanciometría eléctrica; Obesidad; Obesity; Resistin; Resistina; Skeletal muscle mass index; Índice de masa muscular esquelética.