Current Perspectives on the Management of Herpesvirus Infections in Solid Organ Transplant Recipients

S Reshwan K Malahe; Jeroen J A van Kampen; Olivier C Manintveld; Rogier A S Hoek; Caroline M den Hoed; Carla C Baan; Marcia M L Kho; Georges M G M Verjans

doi:10.3390/v15071595

Current Perspectives on the Management of Herpesvirus Infections in Solid Organ Transplant Recipients

Viruses. 2023 Jul 21;15(7):1595. doi: 10.3390/v15071595.

Authors

S Reshwan K Malahe^{1

2}, Jeroen J A van Kampen³, Olivier C Manintveld^{2

4}, Rogier A S Hoek^{2

5}, Caroline M den Hoed^{2

6}, Carla C Baan^{1

2}, Marcia M L Kho^{1

2}, Georges M G M Verjans^{3

7}

Affiliations

¹ Department of Internal Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
² Erasmus MC Transplant Institute, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
³ Department of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
⁴ Department of Cardiology, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
⁵ Department of Pulmonary Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
⁶ Department of Gastroenterology and Hepatology, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
⁷ HerpeslabNL, Department of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.

Abstract

Solid organ transplant recipients (SOTRs) are at high risk of human herpesvirus (HHV)-related morbidity and mortality due to the use of immunosuppressive therapy. We aim to increase awareness and understanding of HHV disease burden in SOTRs by providing an overview of current prevention and management strategies as described in the literature and guidelines. We discuss challenges in both prevention and treatment as well as future perspectives.

Keywords: human herpesviruses; solid organ transplant recipients; solid organ transplantation.

Publication types

Review

MeSH terms

Herpes Simplex*
Herpesviridae Infections* / drug therapy
Herpesviridae Infections* / prevention & control
Herpesvirus 6, Human*
Humans
Organ Transplantation* / adverse effects
Transplant Recipients

Grants and funding

No external funding was received.