Hepatitis Delta Virus-Host Protein Interactions: From Entry to Egress

Susannah Stephenson-Tsoris; T Jake Liang

doi:10.3390/v15071530

Hepatitis Delta Virus-Host Protein Interactions: From Entry to Egress

Viruses. 2023 Jul 11;15(7):1530. doi: 10.3390/v15071530.

Authors

Susannah Stephenson-Tsoris¹, T Jake Liang¹

Affiliation

¹ Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Hepatitis delta virus (HDV) is the smallest known human virus and causes the most severe form of human viral hepatitis, yet it is still not fully understood how the virus replicates and how it interacts with many host proteins during replication. This review aims to provide a systematic review of all the host factors currently known to interact with HDV and their mechanistic involvement in all steps of the HDV replication cycle. Finally, we discuss implications for therapeutic development based on our current knowledge of HDV-host protein interactions.

Keywords: hepatitis; host factors; life cycle; replication; therapeutic development; viral infection.

Publication types

Systematic Review
Review
Research Support, N.I.H., Intramural

MeSH terms

Hepatitis Delta Virus*
Humans
Virus Replication*

Grants and funding

This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA.