Pharmacological Activities of Schiff Bases and Their Derivatives with Low and High Molecular Phosphonates

Pharmaceuticals (Basel). 2023 Jun 28;16(7):938. doi: 10.3390/ph16070938.

Abstract

This review paper is focused on the design of anthracene and furan-containing Schiff bases and their advanced properties as ligands in complex transition metal ions The paper also provides a brief overview on a variety of biological applications, namely, potent candidates with antibacterial and antifungal activity, antioxidant and chemosensing properties. These advantageous properties are enhanced upon metal complexing. The subject of the review has been extended with a brief discussion on reactivity of Schiff bases with hydrogen phosphonates and the preparation of low and high molecular phosphonates, as well as their application as pharmacological agents. This work will be of interest for scientists seeking new challenges in discovering advanced pharmacological active molecules gaining inspiration from the versatile families of imines and aminophosphonates.

Keywords: aminophophonates; anthracene-containing schiff bases; furan-containing Schiff bases; pharmacological activities; poly(aminophosphonate)s.

Publication types

  • Review

Grants and funding

This work was supported by the Operational Program “Science and Education for Smart Growth” 2014–2020, co-financed by European Union through the European Structural and Investment Funds, Grant BG05M2OP001-1.002-0012 “Sustainable utilization of bio-resources and waste of medicinal and aromatic plants for innovative bioactive products”.