Four Undescribed Pyranones from the Scutellaria formosana-Derived Endophytic Fungi Ascomycota sp. FAE17

Jianni Yang; Yang Hui; Zhaoxia Chen; Guangying Chen; Xiaoping Song; Zhenfan Sun; Changri Han; Wenhao Chen

doi:10.3390/molecules28145388

Four Undescribed Pyranones from the Scutellaria formosana-Derived Endophytic Fungi Ascomycota sp. FAE17

Molecules. 2023 Jul 13;28(14):5388. doi: 10.3390/molecules28145388.

Authors

Jianni Yang^{1

2}, Yang Hui^{1

2}, Zhaoxia Chen^{1

2}, Guangying Chen^{1

2}, Xiaoping Song^{1

2}, Zhenfan Sun³, Changri Han³, Wenhao Chen^{1

2}

Affiliations

¹ Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
² Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, China.
³ Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, Hainan Vocational University of Science and Technology, Haikou 571158, China.

Abstract

Four undescribed pyranone derivatives, named ascomycopyrones A-D (1-4), as well as one known analogue simplicilopyrone (5) (this is the first study to report the absolute configuration), were isolated from the endophytic fungus Ascomycota sp. FAE17 derived from the flowers of Scutellaria formosa. The structures of these pyranones were identified by comprehensive spectroscopic and MS analyses, and the absolute configurations were determined by their experimental and quantum chemical electronic circular dichroism (ECD) calculations. All isolated compounds were tested for various bioactivities, including antibacterial, cytotoxic activity, and NO inhibitory activity. Unfortunately, none of the compounds showed significant bioactivities.

Keywords: Ascomycota sp. FAE17; Scutellaria formosa; biological activity; secondary metabolites.

MeSH terms

Ascomycota* / chemistry
Fungi / chemistry
Molecular Structure
Scutellaria*
Taiwan

Abstract

MeSH terms

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