The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential

Fengguang Yang; Jinglin Ma; Daxue Zhu; Zhaoheng Wang; Yanhu Li; Xuegang He; Guangzhi Zhang; Xuewen Kang

doi:10.3390/biom13071139

The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential

Biomolecules. 2023 Jul 17;13(7):1139. doi: 10.3390/biom13071139.

Authors

Fengguang Yang^{1

2

3}, Jinglin Ma^{1

2

3

4}, Daxue Zhu^{1

2

3}, Zhaoheng Wang^{1

2

3}, Yanhu Li^{1

2

3}, Xuegang He^{1

2

3}, Guangzhi Zhang^{1

2

3}, Xuewen Kang^{1

2

3}

Affiliations

¹ Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, China.
² The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China.
³ Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, China.
⁴ School of Petrochemical Engineering, Lanzhou University of Technology, Lanzhou 730050, China.

Abstract

S100A6, also known as calcyclin, is a low-molecular-weight Ca²⁺-binding protein from the S100 family that contains two EF-hands. S100A6 is expressed in a variety of mammalian cells and tissues. It is also expressed in lung, colorectal, pancreatic, and liver cancers, as well as other cancers such as melanoma. S100A6 has many molecular functions related to cell proliferation, the cell cycle, cell differentiation, and the cytoskeleton. It is not only involved in tumor invasion, proliferation, and migration, but also the pathogenesis of other non-neoplastic diseases. In this review, we focus on the molecular mechanisms and potential therapeutic targets of S100A6 in tumors, nervous system diseases, leukemia, endometriosis, cardiovascular disease, osteoarthritis, and other related diseases.

Keywords: Alzheimer’s disease; S100A6; endometriosis; leukemia; myocardial infarction; tumor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Cycle
Cell Cycle Proteins / metabolism
Cell Differentiation
Cell Proliferation
Female
Humans
Liver Neoplasms*
Mammals / metabolism
S100 Calcium Binding Protein A6* / metabolism
S100 Proteins / metabolism

Substances

Cell Cycle Proteins
S100 Calcium Binding Protein A6
S100 Proteins
S100A6 protein, human

Grants and funding

This work had the following financial supports: National Natural Science Foundation of China (Grant Nos. 82272536); Natural Science Foundation of Gansu Province, China (Grant No. 21JR11RA108); University Innovation Fund Project of Gansu Provincial Department of Education (Grant No. 2021B-049); Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital (Grant No. 2020QN-02); Cuiying Student Research and Cultivation Project of Lanzhou University Second Hospital (Grant No. CYXZ2021-20 and CYXZ2021-21).