A novel visible-light photoredox strategy is reported for the efficient dehydroxylative alkylation of a wide array of α-hydroxy carboxylic acid derivatives using diaryl boron radical. The reaction features readily accessible starting materials, broad substrate scope with excellent functionality tolerance. Preliminary mechanistic studies reveal that the spin-center shift process is responsible for the C-O bond activation, which is promoted by the diaryl boron radical generated from bench-stable and commercially available tetraphenyl borate (NaBPh4 ).
Keywords: dehydroxylative alkylation; diaryl boron radical; visible-light catalysis; α-hydroxy carboxylic acid derivatives.
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