Involvement of the SIRT1-NLRP3 pathway in the inflammatory response

Cell Commun Signal. 2023 Jul 28;21(1):185. doi: 10.1186/s12964-023-01177-2.

Abstract

The silent information regulator 2 homolog 1-NACHT, LRR and PYD domains-containing protein 3 (SIRT1-NLRP3) pathway has a crucial role in regulation of the inflammatory response, and is closely related to the occurrence and development of several inflammation-related diseases. NLRP3 is activated to produce the NLRP3 inflammasome, which leads to activation of caspase-1 and cleavage of pro-interleukin (IL)-1β and pro-IL-18 to their active forms: IL-1β and IL-18, respectively. They are proinflammatory cytokines which then cause an inflammatory response.SIRT1 can inhibit this inflammatory response through nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B pathways. This review article focuses mainly on how the SIRT1-NLRP3 pathway influences the inflammatory response and its relationship with melatonin, traumatic brain injury, neuroinflammation, depression, atherosclerosis, and liver damage. Video Abstract.

Keywords: Inflammatory response; LRR and PYD domains-containing protein 3; NACHT; Nuclear factor erythroid 2-related factor 2; Nuclear factor-kappa B; Sirtuin 1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Video-Audio Media

MeSH terms

  • Cytokines / metabolism
  • Humans
  • Inflammasomes / metabolism
  • Interleukin-18* / metabolism
  • Interleukin-1beta / metabolism
  • NLR Family, Pyrin Domain-Containing 3 Protein* / metabolism
  • Sirtuin 1*

Substances

  • Cytokines
  • Inflammasomes
  • Interleukin-18
  • Interleukin-1beta
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Sirtuin 1