Validation of agent-based models of surface receptor oligomerisation

Joanne C Clark; Steve P Watson; Dylan M Owen

doi:10.1016/j.tips.2023.07.002

Validation of agent-based models of surface receptor oligomerisation

Trends Pharmacol Sci. 2023 Oct;44(10):643-646. doi: 10.1016/j.tips.2023.07.002. Epub 2023 Jul 26.

Authors

Joanne C Clark¹, Steve P Watson², Dylan M Owen³

Affiliations

¹ Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK; Centre of Membrane Proteins and Receptors (COMPARE), The Universities of Birmingham and Nottingham, The Midlands, UK. Electronic address: j.clark.5@bham.ac.uk.
² Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK; Centre of Membrane Proteins and Receptors (COMPARE), The Universities of Birmingham and Nottingham, The Midlands, UK.
³ Centre of Membrane Proteins and Receptors (COMPARE), The Universities of Birmingham and Nottingham, The Midlands, UK; Institute of Immunology and Immunotherapy, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.

PMID: 37507263
DOI: 10.1016/j.tips.2023.07.002

Abstract

Receptor dimerisation and higher order oligomerisation regulates signalling by a wide variety of transmembrane receptors. We discuss how agent-based modelling (ABM) combined with advanced microscopy and structural studies can provide new insights into the regulation of clustering, including spatial considerations, revealing novel targets for therapeutic intervention.

Keywords: agent-based modelling; membrane receptors; single-molecule microscopy; super-resolution.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Receptors, Cell Surface* / chemistry
Signal Transduction*

Substances

Receptors, Cell Surface

Abstract

Publication types

MeSH terms

Substances

Grants and funding