Clinical Profile and Pharmacological Management of Snakebites in Community Care Units: A Retrospective Study Using Two Military Hospital Databases in South Thailand

Sethapong Lertsakulbunlue; Ratchakarn Suebtuam; Theethach Eamchotchawalit; Wittawat Chantkran; Janeyuth Chaisakul

doi:10.3390/tropicalmed8070346

Clinical Profile and Pharmacological Management of Snakebites in Community Care Units: A Retrospective Study Using Two Military Hospital Databases in South Thailand

Trop Med Infect Dis. 2023 Jun 29;8(7):346. doi: 10.3390/tropicalmed8070346.

Authors

Sethapong Lertsakulbunlue¹, Ratchakarn Suebtuam², Theethach Eamchotchawalit³, Wittawat Chantkran⁴, Janeyuth Chaisakul¹

Affiliations

¹ Department of Pharmacology, Phramongkutklao College of Medicine, Bangkok 10400, Thailand.
² Fort Thepsatrisrisunthon Hospital, Nakhon Si Thammarat 80310, Thailand.
³ Fort Wachirawut Hospital, Nakhon Si Thammarat 80000, Thailand.
⁴ Department of Pathology, Phramongkutklao College of Medicine, Bangkok 10400, Thailand.

Abstract

Snakebite envenoming is an occupational hazard in remote rural areas of South Thailand, where the highest incidence of snakebites is reported. In this work, a hospital-based retrospective study of snakebite patients from 2012 to 2022 at Fort Wachirawut Hospital and Fort Thepsatrisrisunthon Hospital, located in Nakhon Si Thammarat province, Thailand was conducted. Data from the laboratory investigation, physical examinations of snakebite victims, and clinical management, including pharmacological and non-pharmacological treatments, were evaluated. A total of 54 snakebite victims were included. The median age of patients was 49 years (IQR, 28 to 63). Males accounted for 74.1% of all participants. The majority of patients were bitten by Malayan pit vipers (68.5%), followed by unidentified snakes (18.5%), other non-venomous snakes (7.4%), and cobras (5.6%). The most common clinical manifestations were swelling (90.2%) and local pain (73.2%). One patient experienced respiratory failure following an envenoming by an unidentified venomous snake. No deaths were observed in this study. In total, 24 patients received antivenom administration (44.4%), most of whom were from Fort Wachirawut Hospital. Patients who were administered antivenom showed a median admission duration of three days (IQR, 3 to 4), compared with two days (IQR, one to three) for those who did not receive antivenom treatment (p < 0.001). In addition, paracetamol and prophylactic antibiotics, namely, amoxicillin-clavulanate and dicloxacillin, were the most common pharmacotherapies following snakebites. Overall, it was observed that these two community hospitals undertook appropriate clinical management under the standard guidelines for snakebite patients. This might be due to the effective emergency management, facilities, and clinical consultations. Finally, the management process in the medical teams also plays a crucial role in minimizing the severity of snakebite outcomes.

Keywords: Thailand; antivenom; clinical profiles; military hospitals; snakebites; treatment.

Grants and funding

This research article was supported by the Office of Research Development, Phramongkutklao Hospital and Phramongkutklao College of Medicine (ORDPMK), Bangkok, Thailand.