Exploring ACSL4/LPCAT3/ALOX15 and SLC7A11/GPX4/NFE2L2 as potential targets in ferroptosis-based cancer therapy

Future Med Chem. 2023 Jul;15(14):1209-1212. doi: 10.4155/fmc-2023-0125. Epub 2023 Jul 28.

Gaurav Gupta^{1

2}, Asif Ahmad Bhat¹, Ahsas Goyal³, Neelam Singla¹, Saurabh Gupta⁴, Sanjay Sharma⁵, Shvetank Bhatt⁶, Kamal Dua^{7

8}

¹ School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, Jaipur, India.
² Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Science, Chennai, India.
³ Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.
⁴ Department of Pharmacology, Chameli Devi Institute of Pharmacy, Khandwa Road, Village Umrikheda, Near Toll Booth, Indore, Madhya Pradesh, 452020, India.
⁵ Shri Vile Parle Kelavani Mandal's Narsee Monjee Institute of Management Studies, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, Vile Parle West, Mumbai, Maharashtra, India.
⁶ School of Health Sciences and Technology, Dr. Vishwanath Karad MIT World Peace University, Pune-411038, Maharashtra, India.
⁷ Discipline of Pharmacy, Graduate School of Health, University of Technology, Sydney, New South Wales, 2007, Australia.
⁸ Faculty of Health, Australian Research Center in Complementary & Integrative Medicine, University of Technology, Sydney, New South Wales, 2007, Australia.

No abstract available

Keywords: antioxidants; cancer; drug therapy; ferroptosis; reactive oxygen species.

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