Experimental Study of Coil Compaction: Impact of Pulsatile Stress

Takumi Asai; Yoshitaka Nagano; Tomotaka Ohshima; Shigeru Miyachi

doi:10.5797/jnet.oa.2021-0023

Experimental Study of Coil Compaction: Impact of Pulsatile Stress

J Neuroendovasc Ther. 2022;16(1):12-18. doi: 10.5797/jnet.oa.2021-0023. Epub 2021 May 7.

Authors

Takumi Asai¹, Yoshitaka Nagano², Tomotaka Ohshima³, Shigeru Miyachi³

Affiliations

¹ Department of Neurosurgery, National Hospital Organization, Nagoya Medical Center, Nagoya, Aichi, Japan.
² Department of Electronic Control and Robot Engineering, Aichi University of Technology, Gamagori, Aichi, Japan.
³ Department of Neurological Surgery and Neuroendovascular Therapy Center, Aichi Medical University, Nagakute, Aichi, Japan.

Abstract

Objective: Coil compaction after aneurysm embolization is one of the major issues associated with aneurysm recurrence. On the presumption that pulsatile stress to the aneurysm is responsible for coil compaction, we developed an experimental model in vitro to visualize the mechanical stresses exerted by blood pressure and pulse and their relation to coil compaction.

Methods: A closed-type non-circulation system was developed by installing a syringe that generated pressure at one end of a tube, along with a spherical aneurysm made of silicone and a pressure sensor in the bifurcated end. We installed a fixed-pressure model under a steady pressure of 300 mmHg while the pressure-fluctuation model simulated the pressure variations using a plunger (in a syringe) by using a motor that applied pulsatile stress in the range of 50 mmHg for a 10-ms cycle. We devised four types of aneurysms with different depths and the same coil length. After coil packing, the aneurysms were observed for 3 days (the observation period in the pressure-fluctuation model corresponded to approximately 300 days in real time). The distance from the datum point to the observable coil loops was determined as the initial position, and the temporal change in the distance from that position was measured.

Results: In the fixed-pressure model, the average distance of coil movement was very small (less than ±0.1 mm). In the pressure-fluctuation model, the movement of coils was observed to be significant for the two longest depths (0.11 and 0.14 mm). The maximal dynamic change in coil movement was observed on the second day. The range of movement was observed to decrease thereafter.

Conclusion: Our experimental study enabled the observation of coil movement within a short duration. It examined coil compaction by applying pulsed pressure to the coils at high speeds. Consequently, a shift of the coil loops inside the incompletely occluded aneurysms was detected on applying a pulsed pressure.

Keywords: aneurysm; coil; compaction; embolization; pulse.