Advanced brain age in community-dwelling population with combined physical and cognitive impairments

Chen-Yuan Kuo; Pei-Lin Lee; Li-Ning Peng; Wei-Ju Lee; Pei-Ning Wang; Liang-Kung Chen; Kun-Hsien Chou; Chih-Ping Chung; Ching-Po Lin

doi:10.1016/j.neurobiolaging.2023.06.017

Advanced brain age in community-dwelling population with combined physical and cognitive impairments

Neurobiol Aging. 2023 Oct:130:114-123. doi: 10.1016/j.neurobiolaging.2023.06.017. Epub 2023 Jul 6.

Authors

Chen-Yuan Kuo¹, Pei-Lin Lee¹, Li-Ning Peng², Wei-Ju Lee³, Pei-Ning Wang⁴, Liang-Kung Chen⁵, Kun-Hsien Chou⁶, Chih-Ping Chung⁷, Ching-Po Lin⁸

Affiliations

¹ Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.
² Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Center for Geriatric and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.
³ Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Family Medicine, Taipei Veterans General Hospital Yuanshan Branch, Yi-Lan, Taiwan.
⁴ Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; Brain Research Center and National Yang Ming Chiao Tung University, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
⁵ Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Taipei Municipal Gan-Dau Hospital (managed by Taipei Veterans General Hospital), Taipei, Taiwan.
⁶ Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan; Brain Research Center and National Yang Ming Chiao Tung University, Taipei, Taiwan.
⁷ Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address: cpchung@vghtpe.gov.tw.
⁸ Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan; Brain Research Center and National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address: chingpolin@gmail.com.

PMID: 37499588
DOI: 10.1016/j.neurobiolaging.2023.06.017

Abstract

We investigated whether advanced brain biological age is associated with accelerated age-related physical and/or cognitive functional decline: mobility impairment no disability (MIND), cognitive impairment no dementia (CIND), and physio-cognitive decline syndrome (PCDS). We constructed a brain age prediction model using gray matter features from the magnetic resonance imaging of 1482 healthy individuals (aged 18-92 years). Predicted and chronological age differences were obtained (brain age gap [BAG]) and analyzed in another 1193 community-dwelling population aged ≥50 years. Among the 1193 participants, there were 501, 346, 148, and 198 in the robust, CIND, MIND, and PCDS groups, respectively. Participants with PCDS had significantly larger BAG (BAG = 2.99 ± 8.97) than the robust (BAG = -0.49 ± 9.27, p = 0.002; η² = 0.014), CIND (BAG = 0.47 ± 9.16, p = 0.02; η² = 0.01), and MIND (BAG = 0.36 ± 9.69, p = 0.036; η² = 0.013) groups. Advanced brain aging is involved in the pathophysiology of the co-occurrence of physical and cognitive decline in the older people. The PCDS may be a clinical phenotype reflective of accelerated biological age in community-dwelling older individuals.

Keywords: Accelerated aging; Brain age; Cognitive frailty; Physio-cognitive decline syndrome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brain / diagnostic imaging
Cognitive Dysfunction* / epidemiology
Gray Matter
Humans
Independent Living*