The content of single heavy metal in blood is associated with lung function decline, but there is little evidence on the joint effect of multiple heavy metals on lung function. To explore whether heavy metal mixture exposure is associated with lung function reduction among young adults. The study based on a cohort of 518 students recruited from a college in Shandong, China. We measured their lung function and blood heavy metal concentrations. The BKMR model was used to analyse the association between blood heavy metals mixture levels and lung function, and to identify the critical single heavy metal which contributes most to joint effects. As the sensitivity analysis, we used quantile g-computation model and GLM to explore the joint effect and independent effects of heavy metals. Our findings revealed a significant reduction of FVC and FEV1 levels after exposure to heavy metals mixture. An IQR increase in Cu was associated with a 0.079 L and 0.083 L decrease in FEV1 and FVC, respectively. And an IQR increase in Fe was associated with 0.036 L higher FEV1 and 0.033 L higher FVC. For adults, reducing blood heavy metals concentration might be an effective intervention to protect lung function.
Keywords: Cohort study; Heavy metal; Joint effect; Lung function.
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