Optimal cut-off MoCA score for screening for mild cognitive impairment in elderly individuals in China: A systematic review and meta-analysis

Asian J Psychiatr. 2023 Sep:87:103691. doi: 10.1016/j.ajp.2023.103691. Epub 2023 Jul 14.

Abstract

Aim: To evaluate the optimal cut-off MoCA score for elderly individuals with MCI.

Design: A systematic review and meta-analysis.

Method: Articles were retrieved from PubMed, Ovid, Embase, The Cochrane Library, PsycINFO, CBM, CNKI, WanFang and CQVIP and were assessed by using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Figures of the assessment were made by using Review Manager 5.3, and a meta-analysis of the data was conducted by using Bivariate Random-effects Meta-Analysis (BRMA) via Stata 14.0.

Results: Seventeen articles were retrieved from the database, and when the cut-offs were 24/25 and 25/26, they represented the same diagnostic value; in addition, the AUC was 0.96, which demonstrated high predictive validity for mild cognitive impairment screening. However, the sensitivity was higher with 25/26 (se=0.95, sp=0.80), whereas the specificity was higher with 24/25 (se=0.92, sp=0.89).

Keywords: Cut-off score; Elderly individuals; Mild Cognitive Impairment (MCI); Montreal Cognitive Assessment (MoCA).

Publication types

  • Meta-Analysis
  • Systematic Review
  • Review

MeSH terms

  • Aged
  • China
  • Cognitive Dysfunction* / diagnosis
  • Cognitive Dysfunction* / psychology
  • Humans
  • Neuropsychological Tests
  • Sensitivity and Specificity