Determination of serum and gingival crevicular fluid levels of omentin in healthy and rheumatoid arthritis subjects with and without periodontitis

Jyothi Mohit; Geetha Ari; Jaideep Mahendra; Prashanthi Prakash; Muskan Bedi; Pavithra H Dave; Anitha Logaranjani; Ambalavanan Namasivayam

doi:10.1111/odi.14695

Determination of serum and gingival crevicular fluid levels of omentin in healthy and rheumatoid arthritis subjects with and without periodontitis

Oral Dis. 2023 Jul 27. doi: 10.1111/odi.14695. Online ahead of print.

Authors

Jyothi Mohit¹, Geetha Ari¹, Jaideep Mahendra¹, Prashanthi Prakash¹, Muskan Bedi², Pavithra H Dave¹, Anitha Logaranjani¹, Ambalavanan Namasivayam¹

Affiliations

¹ Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Chennai, India.
² Department of Basic Medical Sciences, Sri Ramachandra Medical College and Research Institute, Chennai, India.

PMID: 37498907
DOI: 10.1111/odi.14695

Abstract

Objective: The aim of this study was to assess and correlate the serum and GCF levels of omentin with the periodontal status of rheumatoid arthritis (RA) patients with and without periodontitis.

Methods: Forty-four patients were divided into four groups: group H: 11 systemically and periodontally healthy subjects; group P: 11 systemically healthy subjects with periodontitis; group RA: 11 periodontally healthy subjects with rheumatoid arthritis and group RA + P: 11 rheumatoid arthritis subjects with periodontitis. Periodontal parameters (plaque index, modified gingival index, probing depth, and clinical attachment level) were recorded and serum and GCF samples were collected for the estimation of omentin using ELISA.

Results: The mean value of plaque index, modified gingival index, probing depth, and clinical attachment level were significantly higher whereas serum and GCF omentin levels were found to be decreased in group IV when compared to the other groups. The significant correlation was found between the serum and GCF omentin levels with all the periodontal parameters.

Conclusion: The omentin level in serum and GCF was found to be lower in RA patients with periodontitis. It is also inversely correlated with the periodontal parameters. Thus, omentin can serve as a significant diagnostic and therapeutic tool in both periodontal and rheumatoid disease.

Keywords: GCF; adipokines; biomarkers; omentin; periodontitis; rheumatoid arthritis; serum.