Vascular disruption agent and phototherapeutic assembled nanoparticles for enhanced tumor inhibition

Tangna Pan; Yuanyu Tang; E Pang; Shaojing Zhao; Chaoyi Yao; Benhua Wang; Xiangzhi Song; Minhuan Lan

doi:10.1039/d3cc02647g

Vascular disruption agent and phototherapeutic assembled nanoparticles for enhanced tumor inhibition

Chem Commun (Camb). 2023 Aug 10;59(65):9896-9899. doi: 10.1039/d3cc02647g.

Authors

Tangna Pan¹, Yuanyu Tang¹, E Pang¹, Shaojing Zhao¹, Chaoyi Yao¹, Benhua Wang^{1

2}, Xiangzhi Song¹, Minhuan Lan¹

Affiliations

¹ Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P. R. China. benhuawang@csu.edu.cn.
² Shenzhen Research Institute of Central South University, Shenzhen 518057, P. R. China.

PMID: 37498195
DOI: 10.1039/d3cc02647g

Abstract

Vascular disruption agent (combretastatin A-4 phosphate) and phototherapeutic (IEICO-4F) assembled nanoparticles (IFC NPs) were prepared for the first time. The IFC NPs have a high photo energy utilization efficiency of up to 96.1%, and could significantly inhibit tumor growth by photodynamic and photothermal therapy enhanced tumor vascular disruption.

MeSH terms

Cell Line, Tumor
Humans
Nanoparticles* / therapeutic use
Neoplasms* / drug therapy
Photochemotherapy*