Polysaccharides from natural resource: ameliorate type 2 diabetes mellitus via regulation of oxidative stress network

Li-Ying He; Yong Li; Shu-Qi Niu; Jing Bai; Si-Jing Liu; Jin-Lin Guo

doi:10.3389/fphar.2023.1184572

Polysaccharides from natural resource: ameliorate type 2 diabetes mellitus via regulation of oxidative stress network

Front Pharmacol. 2023 Jul 11:14:1184572. doi: 10.3389/fphar.2023.1184572. eCollection 2023.

Authors

Li-Ying He¹, Yong Li¹, Shu-Qi Niu^{2

3}, Jing Bai², Si-Jing Liu^{2

3}, Jin-Lin Guo^{1

2

3}

Affiliations

¹ Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
² College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
³ Chongqing Key Laboratory of Sichuan-Chongqing Co Construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Chongqing, China.

Abstract

Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia that can occur in children, adults, elderly people, and pregnant women. Oxidative stress is a significant adverse factor in the pathogenesis of DM, especially type 2 diabetes mellitus (T2DM), and metabolic syndrome. Natural polysaccharides are macromolecular compounds widely distributed in nature. Some polysaccharides derived from edible plants and microorganisms were reported as early as 10 years ago. However, the structural characterization of polysaccharides and their therapeutic mechanisms in diabetes are relatively shallow, limiting the application of polysaccharides. With further research, more natural polysaccharides have been reported to have antioxidant activity and therapeutic effects in diabetes, including plant polysaccharides, microbial polysaccharides, and polysaccharides from marine organisms and animals. Therefore, this paper summarizes the natural polysaccharides that have therapeutic potential for diabetes in the past 5 years, elucidating their pharmacological mechanisms and identified primary structures. It is expected to provide some reference for the application of polysaccharides, and provide a valuable resource for the development of new diabetic drugs.

Keywords: diabetes mellitus; mechanism; metabolism; natural polysaccharide; oxidative stress.

Publication types

Review

Grants and funding

This work was supported by the National Natural Sciences Foundation of China (Nos. 81872959, 81373920, 30801522, 82003900). “Xinglin Scholar” Talent Research Promotion Plan of Chengdu University of Traditional Chinese Medicine (No. ZYTS2019022). Young Science and Technology Innovation Team of Sichuan Province (No. 2019CXTD0055).