C-reactive protein, D-dimer, erythrocyte sedimentation rate, and troponin in intensive care unit patients with COVID-19 in Iran

Hassan Salehi; Bahram Pakzad; Marzieh Salehi; Saeed Abbasi; Mohammad Mahdi Salehi; Maryam Kazemi Naeini

doi:10.4103/jrms.jrms_352_22

C-reactive protein, D-dimer, erythrocyte sedimentation rate, and troponin in intensive care unit patients with COVID-19 in Iran

J Res Med Sci. 2023 Jun 28:28:56. doi: 10.4103/jrms.jrms_352_22. eCollection 2023.

Authors

Hassan Salehi¹, Bahram Pakzad², Marzieh Salehi³, Saeed Abbasi⁴, Mohammad Mahdi Salehi⁵, Maryam Kazemi Naeini⁶

Affiliations

¹ Infectious Diseases and Tropical Medicine Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
² Department of Internal Medicine, Division of Rheumatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
⁴ Anesthesiology and Critical Care Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
⁵ Department of Oral Health Science, Faculty of Dentistry, University of British Columbia, Endowment Lands, Canada.
⁶ Department Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic in Iran has led to a lack of intensive care unit (ICU) facilities. This study examines C-reactive protein (CRP), D-dimer, erythrocyte sedimentation rate (ESR), and troponin in ICU patients with COVID-19 in comparison to COVID-19 patients admitted to the wards in Iran.

Materials and methods: In a case-control study, troponin, CRP, ESR, and D-dimer were compared in the case samples of 109 COVID-19 patients admitted to the ICU, and in the control group, 140 COVID-19 patients admitted to the wards.

Results: The mean of CRP (P < 0.001) and D-dimer (P < 0.001) was higher, whereas troponin (P < 0.001) was lower in patients admitted to the ICU, but no significant difference was observed between the values of ESR (P = 0.292) in the two groups.

Conclusion: This study showed that the values of CRP and D-dimer were higher in patients admitted to the ICU, but no significant difference was observed between the values of ESR in the two groups.

Keywords: Coronavirus disease 2019; intensive care unit admission; prognostic factors.