MicroRNA profiles in critically ill patients

Babak Alikiaii; Mohammad Bagherniya; Gholamreza Askari; Rajkumar Rajendram; Amirhossein Sahebkar

doi:10.2174/0929867331666230726095222

MicroRNA profiles in critically ill patients

Curr Med Chem. 2023 Jul 26. doi: 10.2174/0929867331666230726095222. Online ahead of print.

Authors

Babak Alikiaii¹, Mohammad Bagherniya^{1

2

3}, Gholamreza Askari^{1

2

3}, Rajkumar Rajendram^{4

5}, Amirhossein Sahebkar^{6

7

8}

Affiliations

¹ Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
² Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
⁴ Department of Medicine, King Abdulaziz Medical City, King Abdulaziz International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.
⁵ College of Medicine, King Saud bin Abdulaziz University of Health Sciences, Riyadh, Saudi Arabia.
⁶ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
⁷ Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁸ Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 37496239
DOI: 10.2174/0929867331666230726095222

Abstract

The use of biomarkers to expedite diagnosis, prognostication, and treatment could significantly improve patient outcomes. The early diagnosis and treatment of critical illnesses can greatly reduce mortality and morbidity. Therefore, there is great interest in the discovery of biomarkers for critical illnesses. Micro-ribonucleic acids (miRNAs) are a highly conserved group of non-coding RNA molecules. They regulate the expression of genes involved in several developmental, physiological, and pathological processes. The characteristics of miRNAs suggest that they could be versatile biomarkers. Assay panels to measure the expression of several miRNAs could facilitate clinical decision-making for a range of diseases. We have, in this paper, reviewed the current understanding of the role of miRNAs as biomarkers in critically ill patients.

Keywords: Micro-ribonucleic acids; biomarkers; critical illnesses; morbidity; mortality; review.