The interplay between lipid droplets and virus infection

Yafei Qu; Weili Wang; Maggie Z X Xiao; Yuejuan Zheng; Qiming Liang

doi:10.1002/jmv.28967

The interplay between lipid droplets and virus infection

J Med Virol. 2023 Jul;95(7):e28967. doi: 10.1002/jmv.28967.

Authors

Yafei Qu^{1

2}, Weili Wang^{1

2}, Maggie Z X Xiao³, Yuejuan Zheng^{4

5}, Qiming Liang^{1

2}

Affiliations

¹ Center for Immune-Related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³ Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
⁴ The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai University of Traditional Medicine, Shanghai, China.
⁵ Center for Traditional Chinese Medicine and Immunology Research, School of Basic Medical Sciences, Shanghai University of Traditional Medicine, Shanghai, China.

PMID: 37496184
DOI: 10.1002/jmv.28967

Abstract

As an intracellular parasite, the virus usurps cellular machinery and modulates cellular metabolism pathways to replicate itself in cells. Lipid droplets (LDs) are universally conserved energy storage organelles that not only play vital roles in maintaining lipid homeostasis but are also involved in viral replication. Increasing evidence has demonstrated that viruses take advantage of cellular lipid metabolism by targeting the biogenesis, hydrolysis, and lipophagy of LD during viral infection. In this review, we summarize the current knowledge about the modulation of cellular LD by different viruses, with a special emphasis on the Hepatitis C virus, Dengue virus, and SARS-CoV-2.

Keywords: lipid droplet; lipid metabolism; lipophagy; virus replication.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19* / metabolism
Hepacivirus
Humans
Lipid Droplets* / metabolism
Lipid Metabolism
SARS-CoV-2