Magnetic Resonance Guided Focused Ultrasound Thalamotomy for Treatment of Severe Essential Tremor in a Lung Transplant Recipient-A Case Report

Pranav Modi; Liming Qiu; Tara Fallah; Andrew Courtwright; Casey H Halpern

doi:10.1016/j.transproceed.2023.06.012

Magnetic Resonance Guided Focused Ultrasound Thalamotomy for Treatment of Severe Essential Tremor in a Lung Transplant Recipient-A Case Report

Transplant Proc. 2023 Oct;55(8):1988-1990. doi: 10.1016/j.transproceed.2023.06.012. Epub 2023 Jul 24.

Authors

Pranav Modi¹, Liming Qiu², Tara Fallah³, Andrew Courtwright⁴, Casey H Halpern⁵

Affiliations

¹ Advanced Lung Diseases and Lung Transplantation, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: pranavdmodiresearch@gmail.com.
² Department of Neurosurgery, Pennsylvania Hospital, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania.
³ Ohio State University Wexner Medical Center, Columbus, Ohio.
⁴ Advanced Lung Diseases and Lung Transplantation, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
⁵ Department of Neurosurgery, Pennsylvania Hospital, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania; Department of Surgery, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania.

PMID: 37495484
DOI: 10.1016/j.transproceed.2023.06.012

Abstract

Calcineurin inhibitor-related tremors occur in up to 50% of solid organ transplant recipients and are disabling in severe cases. We describe a bilateral lung transplant recipient with essential tremors that significantly worsened after tacrolimus initiation. She did not have improvement with the change to extended-release tacrolimus, the use of everolimus as a calcineurin inhibitor-sparing agent, or the addition of primidone, clonazepam, or propranolol. She underwent magnetic resonance-guided focused ultrasound thalamotomy with significant improvement in her tremor and activities of daily living.