Metabolic-Associated Fatty Liver Disease in Childhood and Adolescence

Abstract

Metabolic-associated fatty liver disease (MAFLD) has become the most common cause for chronic liver disease among children and adolescents globally. Although liver biopsy remains the gold standard for diagnosis, emerging technology, like velocity controlled transient elastography, a noninvasive method, is being utilized to evaluate degree of fibrosis in these patients. The discovery of multiple gene polymorphisms has brought new hope for possible treatment targets. However, this research is still ongoing, making lifestyle changes and weight reduction the current mainstay of treatment. This review briefly reviews the most recent data regarding the epidemiology, pathophysiology, diagnostic modalities, and treatment of pediatric MAFLD.

Keywords: Fatty liver; Metabolic syndrome; Metabolic-associated fatty liver disease; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis.