Associations of Life's Essential 8 and fine particulate matter pollution with the incidence of atrial fibrillation

Junguo Zhang; Ge Chen; Hui Xia; Xiaojie Wang; ChongJian Wang; Miao Cai; Yanhui Gao; Gregory Y H Lip; Hualiang Lin

doi:10.1016/j.jhazmat.2023.132114

Associations of Life's Essential 8 and fine particulate matter pollution with the incidence of atrial fibrillation

J Hazard Mater. 2023 Oct 5:459:132114. doi: 10.1016/j.jhazmat.2023.132114. Epub 2023 Jul 22.

Authors

Junguo Zhang¹, Ge Chen¹, Hui Xia², Xiaojie Wang¹, ChongJian Wang³, Miao Cai¹, Yanhui Gao⁴, Gregory Y H Lip⁵, Hualiang Lin⁶

Affiliations

¹ Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
² Center for Health Care, Longhua District, Shenzhen, China.
³ Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
⁴ Department of Medical Statistics, School of Basic Medicine and Public Health, Jinan University, Guangzhou, China; Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
⁵ Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
⁶ Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China. Electronic address: linhualiang@mail.sysu.edu.cn.

PMID: 37494795
DOI: 10.1016/j.jhazmat.2023.132114

Abstract

Both unhealthy lifestyle factors and ambient air pollution have been closely linked with the risk of atrial fibrillation (AF). We retrieved 250,898 participants without AF at baseline from UK Biobank. LE8 was determined by 8 metrics, and was characterized as low, moderate and high cardiovascular health (CVH). Exposure to PM_2.5 was estimated at the geocoded residential address of each participant. During a median follow-up of 12.46 years, we identified 14,743 (5.9%) incident AF cases. Participants with moderate and high CVH showed a decreased risk of incident AF compared to those with low CVH. Of the LE8 metrics, ideal body mass index (BMI) and blood pressure (BP) were associated with a decrease of 11.57% and 11.46% AF cases. High PM_2.5 exposure was associated with an 8% increased risk of AF as compared to low PM_2.5 exposure. Compared with those who had low CVH and high PM_2.5 exposure, participants with a high CVH and low PM_2.5 exposure had the lower AF incidence. Our study found higher CVH is protective, while higher PM_2.5 might be one risk factor of AF. Adherence to the LE8 guidelines may help reduce the incidence of AF, especially in those with lower PM_2.5 exposure.

Keywords: Atrial fibrillation; Cardiovascular health; Life’s Essential 8; PM(2.5).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Air Pollution*
Atrial Fibrillation* / chemically induced
Atrial Fibrillation* / epidemiology
Humans
Incidence
Particulate Matter / toxicity
Risk Factors

Substances

Particulate Matter