Short-term nitisinone discontinuation of hereditary tyrosinemia type 1 mice causes metabolic alterations in glutathione metabolism/biosynthesis and multiple amino acid degradation pathways

Affiliations

• ¹ Vrije Universiteit Brussel, Liver Therapy & Evolution Team, In Vitro Toxicology and Dermato-Cosmetology (IVTD) Research Group, Faculty of Medicine and Pharmacy, Laarbeeklaan 103, Brussels B-1090, Belgium.
• ² Vrije Universiteit Brussel, Experimental Pharmacology (EFAR) Research Group, Faculty of Medicine and Pharmacy, Laarbeeklaan 103, Brussels B-1090, Belgium.
• ³ University of Liverpool, Dept. of Musculoskeletal & Ageing Science, Institute of Life Course & Medical Sciences, Liverpool L7 8TX, United Kingdom.
• ⁴ Vrije Universiteit Brussel, Interfaculty Center Data Processing and Statistics, Faculty of Medicine and Pharmacy, Laarbeeklaan 103, Brussels B-1090, Belgium.
• ⁵ Liverpool University Hospitals NHS Foundation Trust, Clinical Biochemistry and Metabolic Medicine, Liverpool L3 5PS, United Kingdom.
• ⁶ Université Libre de Bruxelles, Laboratoire de Pédiatrie, Brussels B-1050, Belgium.
• ⁷ Vrije Universiteit Brussel, In Vitro Liver Disease Modelling Team, In Vitro Toxicology and Dermato-Cosmetology (IVTD) Research Group, Faculty of Medicine and Pharmacy, Laarbeeklaan 103, Brussels B-1090, Belgium.
• ⁸ AZ Delta General Hospital, Department of Laboratory Medicine, Roeselare 8800, Belgium.
• ⁹ Ghent University, Department of Biomolecular Medicine, Ghent 9052, Belgium.