Hydrogen sulfide-induced post-translational modification as a potential drug target

Hao-Jie Chen; Lei Qian; Ke Li; Yang-Zhe Qin; Jing-Jing Zhou; Xin-Ying Ji; Dong-Dong Wu

doi:10.1016/j.gendis.2022.03.022

Hydrogen sulfide-induced post-translational modification as a potential drug target

Genes Dis. 2022 Apr 20;10(5):1870-1882. doi: 10.1016/j.gendis.2022.03.022. eCollection 2023 Sep.

Authors

Hao-Jie Chen^{1

2}, Lei Qian^{1

2}, Ke Li^{1

2}, Yang-Zhe Qin^{1

2}, Jing-Jing Zhou^{1

2}, Xin-Ying Ji^{1

2

3}, Dong-Dong Wu^{1

2

4}

Affiliations

¹ School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
² Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, Kaifeng, Henan 475004, China.
³ Kaifeng Key Laboratory of Infection and Biological Safety, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
⁴ School of Stomatology, Henan University, Kaifeng, Henan 475004, China.

Abstract

Hydrogen sulfide (H₂S) is one of the three known gas signal transducers, and since its potential physiological role was reported, the literature on H₂S has been increasing. H₂S is involved in processes such as vasodilation, neurotransmission, angiogenesis, inflammation, and the prevention of ischemia-reperfusion injury, and its mechanism remains to be further studied. At present, the role of post-translational processing of proteins has been considered as a possible mechanism for the involvement of H₂S in a variety of physiological processes. Current studies have shown that H₂S is involved in S-sulfhydration, phosphorylation, and S-nitrosylation of proteins, etc. This paper focuses on the effects of protein modification involving H₂S on physiological and pathological processes, looking forward to providing guidance for subsequent research.

Keywords: Hydrogen sulfide; Modification; Phosphorylation; S-nitrosylation; S-sulfhydration.

Publication types

Review