Assembly of mitochondrial succinate dehydrogenase in human health and disease

Ke Cao; Jie Xu; Wenli Cao; Xueqiang Wang; Weiqiang Lv; Mengqi Zeng; Xuan Zou; Jiankang Liu; Zhihui Feng

doi:10.1016/j.freeradbiomed.2023.07.023

Assembly of mitochondrial succinate dehydrogenase in human health and disease

Free Radic Biol Med. 2023 Oct:207:247-259. doi: 10.1016/j.freeradbiomed.2023.07.023. Epub 2023 Jul 23.

Authors

Ke Cao¹, Jie Xu², Wenli Cao², Xueqiang Wang³, Weiqiang Lv², Mengqi Zeng³, Xuan Zou⁴, Jiankang Liu⁵, Zhihui Feng⁶

Affiliations

¹ Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China; Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
² Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China.
³ School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266071, China.
⁴ National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, China.
⁵ Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China; School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266071, China. Electronic address: j.liu@mail.xjtu.edu.cn.
⁶ Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China; School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266071, China. Electronic address: zhfeng@mail.xjtu.edu.cn.

PMID: 37490987
DOI: 10.1016/j.freeradbiomed.2023.07.023

Abstract

Mitochondrial succinate dehydrogenase (SDH), also known as electron transport chain (ETC) Complex II, is the only enzyme complex engaged in both oxidative phosphorylation and the tricarboxylic acid (TCA) cycle. SDH has received increasing attention due to its crucial role in regulating mitochondrial metabolism and human health. Despite having the fewest subunits among the four ETC complexes, functional SDH is formed via a sequential and well-coordinated assembly of subunits. Along with the discovery of subunit-specific assembly factors, the dynamic involvement of the SDH assembly process in a broad range of diseases has been revealed. Recently, we reported that perturbation of SDH assembly in different tissues leads to interesting and distinct pathophysiological changes in mice, indicating a need to understand the intricate SDH assembly process in human health and diseases. Thus, in this review, we summarize recent findings on SDH pathogenesis with respect to disease and a focus on SDH assembly.

Keywords: Mitochondria; Succinate dehydrogenase; Succinate dehydrogenase assembly factors; Tricarboxylic acid cycle.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Citric Acid Cycle*
Humans
Mice
Mitochondria / metabolism
Multienzyme Complexes / metabolism
Oxidative Phosphorylation
Succinate Dehydrogenase* / genetics
Succinate Dehydrogenase* / metabolism

Substances

Succinate Dehydrogenase
Multienzyme Complexes