Stimuli-responsive electrospun nanofibers for drug delivery, cancer therapy, wound dressing, and tissue engineering

J Nanobiotechnology. 2023 Jul 24;21(1):237. doi: 10.1186/s12951-023-01987-z.

Abstract

The stimuli-responsive nanofibers prepared by electrospinning have become an ideal stimuli-responsive material due to their large specific surface area and porosity, which can respond extremely quickly to external environmental incitement. As an intelligent drug delivery platform, stimuli-responsive nanofibers can efficiently load drugs and then be stimulated by specific conditions (light, temperature, magnetic field, ultrasound, pH or ROS, etc.) to achieve slow, on-demand or targeted release, showing great potential in areas such as drug delivery, tumor therapy, wound dressing, and tissue engineering. Therefore, this paper reviews the recent trends of stimuli-responsive electrospun nanofibers as intelligent drug delivery platforms in the field of biomedicine.

Keywords: Biomedicine; Drug delivery; Electrospinning; Nanofibers; Stimuli-responsive.

Publication types

  • Review

MeSH terms

  • Bandages
  • Drug Delivery Systems
  • Humans
  • Nanofibers*
  • Neoplasms* / drug therapy
  • Tissue Engineering