Klotho gene was originally discovered as an anti-aging gene, Klotho protein encoded by Klotho gene is expressed in multiple human tissues, and its most prominent function is the regulation of phosphate homeostasis. Klotho protein possesses various activities, including inhibition of multiple signaling pathways, reducing oxidative stress and suppressing inflammation, and these activities are associated with cancer. Klotho protein is discovered as a universal tumor suppressor, and its expression is associated with tumorigenesis and prognosis of patients. Lung cancer is the most common malignancy tumor, and it is the leading cause of cancer deaths worldwide because of its high incidence and mortality. This article summarizes the research progress of the role of Klotho on pathogenesis, therapeutic effect and prognosis in lung cancer, in order to provide new biomarker and target for diagnosis, treatment and prognosis of lung cancer. .
【中文题目：Klotho在肺癌中的研究进展】 【中文摘要：Klotho基因最早作为一种抗衰老基因被发现，其编码的Klotho蛋白在人类的多种组织中都有表达，该蛋白最显著的功能是调节磷酸盐稳态。Klotho蛋白有抑制相关信号通路、降低氧化应激并抑制炎症反应的作用，而这些过程与癌症发生密切相关。Klotho蛋白是多种恶性肿瘤的抑制因子，其表达与肿瘤的发生发展和患者预后都有关系。肺癌是最常见的恶性肿瘤之一，其发病率和死亡率在所有恶性肿瘤中位居前列。本文就Klotho与肺癌的发病机制、治疗预后关系的研究进展进行综述，对探索与肺癌的诊疗预后相关的新标志物和新靶点有重要意义。 】 【中文关键词：肺肿瘤；Klotho；发病机制；治疗；预后】.
Keywords: Klotho; Lung neoplasms; Pathogenesis; Prognosis; Treatment.