Tracking Clonal Evolution of EGFR-Mutated Non-Small Cell Lung Cancer Through Liquid Biopsy: Management of C797S Acquired Mutation

Alessandro Russo; Katherine A Scilla; Ranee Mehra; Allison Gittens; Michael G McCusker; Diego de Miguel-Perez; Jorge E Gomez; Ariel Peleg; Marzia Del Re; Christian D Rolfo

doi:10.1016/j.cllc.2023.07.003

Tracking Clonal Evolution of EGFR-Mutated Non-Small Cell Lung Cancer Through Liquid Biopsy: Management of C797S Acquired Mutation

Clin Lung Cancer. 2023 Nov;24(7):660-665. doi: 10.1016/j.cllc.2023.07.003. Epub 2023 Jul 19.

Authors

Affiliations

¹ Marlene and Stewart Greenebaum Comprehensive Cancer Center, Division of Hematology/Oncology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD; Department of Onco-Hematology, Papardo Hospital, Messina, Italy.
² Marlene and Stewart Greenebaum Comprehensive Cancer Center, Division of Hematology/Oncology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.
³ Marlene and Stewart Greenebaum Comprehensive Cancer Center, Division of Hematology/Oncology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD; Shenandoah Oncology Associates, Oncology Department, Winchester, VA.
⁴ Marlene and Stewart Greenebaum Comprehensive Cancer Center, Division of Hematology/Oncology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD; Center for Thoracic Oncology, Tisch Cancer Institute, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY.
⁵ Center for Thoracic Oncology, Tisch Cancer Institute, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY.
⁶ Center for Thoracic Oncology, Tisch Cancer Institute, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY; Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
⁷ Center for Thoracic Oncology, Tisch Cancer Institute, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: christian.rolfo@mssm.edu.

PMID: 37487787
DOI: 10.1016/j.cllc.2023.07.003

No abstract available

Keywords: Acquired resistance; Liquid biopsy; Osimertinib; Plasma NGS; Rechallenge.

Publication types

Case Reports

MeSH terms

Carcinoma, Non-Small-Cell Lung* / diagnosis
Carcinoma, Non-Small-Cell Lung* / drug therapy
Carcinoma, Non-Small-Cell Lung* / genetics
Clonal Evolution
Drug Resistance, Neoplasm / genetics
ErbB Receptors / genetics
Humans
Liquid Biopsy
Lung Neoplasms* / diagnosis
Lung Neoplasms* / drug therapy
Lung Neoplasms* / genetics
Mutation / genetics
Protein Kinase Inhibitors / pharmacology

Substances

ErbB Receptors
Protein Kinase Inhibitors
EGFR protein, human