The potential therapeutic effects of Galbanic acid on cancer

Elahe Raji; Vahid Vahedian; Pezhman Golshanrad; Reza Nahavandi; Parisa Behshood; Nahal Soltani; Mahdi Gharibi; Mohsen Rashidi; Nazila Fathi Maroufi

doi:10.1016/j.prp.2023.154686

The potential therapeutic effects of Galbanic acid on cancer

Pathol Res Pract. 2023 Aug:248:154686. doi: 10.1016/j.prp.2023.154686. Epub 2023 Jul 13.

Authors

Elahe Raji¹, Vahid Vahedian², Pezhman Golshanrad³, Reza Nahavandi⁴, Parisa Behshood⁵, Nahal Soltani⁶, Mahdi Gharibi⁷, Mohsen Rashidi⁸, Nazila Fathi Maroufi⁹

Affiliations

¹ Department of Biology, Shahrekord Branch, Islamic Azad University, Iran.
² Department of Hematology, Transfusion Medicine and Cellular Therapy, Division of Hematology/oncology, Clinical Hospital, Faculty of Medicine, University of Sao Paulo (FMUSP-HC), Sao Paulo, Brazil; Department of Clinical Medicine, Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM/31), Faculty of Medicine, University of Sao Paulo (FMUSP), Sao Paulo, Brazil.
³ Sharif University of Technology (International Campus) Department of Computer Eng, Iran.
⁴ Department of Biochemical and Pharmaceutical Engineering, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran 11155-4563, Iran.
⁵ Department of Microbiology, Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Iran.
⁶ Department of Medical Laboratory Sciences, Faculty of Medicine, Islamic Azad University (IAU), Marand, Iran.
⁷ Department of pharmacy, Faculty of Pharmacy, University of Ankara, Ankara, Turkey.
⁸ The Department of Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: dr.mohsenrashidi@yahoo.com.
⁹ Department of Human Genetics, McGill University, Montreal, Canada; Victor Philip Dahdaleh Institute of Genomic Medicine at McGill University, Montreal, Canada; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: nazila.fathimaroufi@mail.mcgill.ca.

PMID: 37487315
DOI: 10.1016/j.prp.2023.154686

Abstract

Galbanic acid (GBA), as a natural compound has potential anticancer properties. It has been documented that GBA shows promising therapeutic potential against various types of cancer, including breast, lung, colon, liver, and prostate cancer. Several mechanisms involve im anti-tumor effects of GBA include apoptosis induction, cell cycle arrest, inhibition of angiogenesis, suppression of metastasis, and modulation of immune responses. Furthermore, the synergistic effects of GBA along with chemotherapeutic agents led to has enhancing efficiency with reduction in toxicity. Moreover, GBA through antioxidant and anti-inflammatory properties possess indirect anti-tumor effects. In this review, we will summarize the anti-tumor effects of GBA acid along with involve mechanisms.

Keywords: Angiogenesis; CSCs; Cancer; GBA; Treatment.

Publication types

Review

MeSH terms

Antineoplastic Agents* / pharmacology
Antineoplastic Agents* / therapeutic use
Apoptosis
Cell Line, Tumor
Coumarins / pharmacology
Coumarins / therapeutic use
Humans
Male
Prostatic Neoplasms*

Substances

galbanic acid
Coumarins
Antineoplastic Agents