In December 2022, highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus emerged in Chile. We detected H5N1 virus in 93 samples and obtained 9 whole-genome sequences of strains from wild birds. Phylogenetic analysis suggests multiple viral introductions into South America. Continued surveillance is needed to assess risks to humans and domestic poultry.
Keywords: Avian influenza virus; Chile; H5N1 subtype; influenza; influenza A virus; respiratory infections; viral dissemination; viruses; wild birds; zoonoses.